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December 1, 1989Circulation Research

Outward potassium currents in freshly isolated smooth muscle cell of dog coronary arteries.

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Population

Single coronary smooth muscle cells freshly isolated from adult beagle dogs

Design

Preclinical

Authors

DWDixon W. WildeKLK S Lee

Discussion

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Overview

Distinguishes two Ca2+-sensitive K+ currents in canine coronary myocytes; leaves open their roles in human vasoregulation.

Structured PICO

P
Population
Single coronary smooth muscle cells freshly isolated from adult beagle dogs
I
Intervention
Voltage clamp using suction pipette method with various pharmacological and ionic manipulations (acetylcholine, high K+, tetraethylammonium, Ba2+, Cs+, Ca2+, Co2+, Bay K 8644)
O
Outcome
Characterization of outward membrane potassium currentssurrogate

This study identifies two distinct types of calcium-sensitive potassium currents in dog coronary smooth muscle cells, highlighting the role of inward calcium channels in modulating these currents.

Cite This Study

Wilde et al. (1989) studied this question.

synapsesocial.com/papers/6a71504435aa2c282ce29ecdhttps://doi.org/10.1161/01.res.65.6.1718
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