Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1993The Journal of PhysiologyOpen Access

Control of resting membrane potential by delayed rectifier potassium currents in ferret airway smooth muscle cells.

View Full Paper
Ask AI
Bookmark
Share

Population

Freshly dissociated ferret trachealis cells and isolated strips of trachealis muscle

Comparison

4-Aminopyridine and charybdotoxin; temperature… vs Baseline/control conditions

Design

Preclinical

Authors

BFBernd K. FleischmannElectrophysiologyRWRobert J. WashabauUniversity of the SciencesMKMichael I. KotlikoffElectrophysiology

Discussion

Loading...

Member takes

Implication

Prioritizes delayed rectifiers over BKCa for airway tone research; leaves open human translation.

Structured PICO

P
Population
Freshly dissociated ferret trachealis cells and isolated strips of trachealis muscle
I
Intervention
4-Aminopyridine (4-AP) and charybdotoxin; temperature variation (22 to 35 degrees C)
C
Comparator
Baseline/control conditions
O
Outcome
Potassium currents (magnitude, conductance, kinetics), resting membrane potential, and baseline tensionsurrogate

Delayed rectifier potassium currents, rather than calcium-activated potassium channels, primarily control the resting membrane potential and resting tone in ferret airway smooth muscle cells.

Cite This Study

Fleischmann et al. (1993) studied this question.

synapsesocial.com/papers/6a80c829d6e5d64541933db9https://doi.org/10.1113/jphysiol.1993.sp019834
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potassium currents in canine airway smooth muscle cells1990 · 46 citations
  2. 2Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions1991 · 175 citations
  3. 3Length-Tension Relationship of Smooth Muscle of the Hog Carotid Artery1973 · 311 citations
  4. 4Effects of tetraethylammonium and 4‐aminopyridine on outward currents and excitability in canine tracheal smooth muscle cells1990 · 64 citations
  5. 5Calcium‐activated potassium channels in canine airway smooth muscle.1986 · 159 citations