October 1, 1992The Journal of PhysiologyOpen Access

Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia.

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Population

Cultured parasympathetic neurones dissociated from neonatal rat intracardiac ganglia

Comparison

Pharmacological channel blockers and ionic… vs Baseline/control conditions

Design

Preclinical

Authors

ZXZijian XuQingdao University DADavid J. AdamsUniversity of Wollongong

Discussion

Member takes

Implication

Caution against clinical extrapolation; leaves open translation of rat intracardiac neuron properties to human autonomic regulation.

Structured PICO

Population

Cultured parasympathetic neurones dissociated from neonatal rat intracardiac ganglia

Intervention

Pharmacological channel blockers (TEA, Ba2+, ouabain, TTX, Cd2+) and ionic substitutions (K+-free medium, internal Cs+)

Comparator

Baseline/control conditions

Outcome

Resting membrane potential, action potential characteristics, and whole-cell K+ currentssurrogate

This preclinical study characterizes the resting membrane potential and potassium currents in neonatal rat intracardiac parasympathetic neurons, detailing the specific ionic contributions to their electrophysiological properties.

Cite This Study

Xu et al. (1992) studied this question.

synapsesocial.com/papers/6a7d2606e6f633beba6e4c06 https://doi.org/10.1113/jphysiol.1992.sp019343

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