Key result
Three different potassium currents (IC, IA, and IK) contribute to action potential repolarization in neonatal rat spinal motoneurones.
Population
Neonatal rat lumbar spinal cord slices
Comparison
Application of tetrodotoxin, tetraethylammonium… vs Control solution
Design
Preclinical
Authors
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Should not inform clinical practice; leaves open translation of these currents to human motoneurone disorders.
This study characterizes the specific potassium currents (IC, IA, and IK) responsible for action potential repolarization in neonatal rat spinal motoneurones.
Tomoyuki Takahashi (1990) studied Neonatal rat spinal cord motoneurones. Ion channel blockers (TTX, TEA, 4-AP) and ion substitution vs. Control solution was evaluated on Membrane currents and action potential repolarization. Three different potassium currents (IC, IA, and IK) contribute to action potential repolarization in neonatal rat spinal motoneurones.
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