December 1, 1983Journal of Neurophysiology

Membrane currents of cultured rat sympathetic neurons under voltage clamp

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Population

Sympathetic neurons dissociated from neonatal rat superior cervical ganglia

Design

Preclinical

Authors

JFJoseph E. FreschiNew York State Department of Health

Discussion

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Implication

Foundational ion current profiles in rat sympathetic neurons; leaves open translation to human cardiovascular autonomic regulation.

Structured PICO

Population

Sympathetic neurons dissociated from neonatal rat superior cervical ganglia

Intervention

Voltage clamp with two microelectrodes, depolarization/hyperpolarization, and application of channel-blocking chemicals (tetraethylammonium, cobalt, muscarine)

Outcome

Characterization of membrane currents based on voltage- and time-dependent propertiessurrogate

This study characterizes seven distinct membrane currents in cultured rat sympathetic neurons, providing a foundation for understanding their electrophysiological properties.

Limitations

Channel-blocking chemicals may lack specificity, especially when used to study potassium channels.

Cite This Study

Joseph E. Freschi (1983) studied this question.

synapsesocial.com/papers/6a7d2606e6f633beba6e4c0e https://doi.org/10.1152/jn.1983.50.6.1460

View Full Paper

Ask AI

Bookmark

Membrane currents of cultured rat sympathetic neurons under voltage clamp

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Membrane currents of cultured rat sympathetic neurons under voltage clamp

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider