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June 1, 1995The Journal of PhysiologyOpen Access

Potassium currents in rat prevertebral and paravertebral sympathetic neurones: control of firing properties.

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Population

Rat sympathetic neurones in isolated superior cervical ganglia, coeliac ganglia and superior mesenteric…

Comparison

Intracellular recordings, single-electrode… vs Phasic versus tonic neurones

Design

Preclinical

Authors

HWH S WangStony Brook UniversityDMDavid McKinnonState University of New York

Discussion

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Implication

Supports M-current role in sympathetic firing diversity; hypothesis-generating for autonomic control, no clinical implications yet.

Structured PICO

P
Population
Rat sympathetic neurones in isolated superior cervical ganglia (SCG), coeliac ganglia (CG) and superior mesenteric ganglia (SMG)
I
Intervention
Intracellular recordings, single-electrode voltage-clamp recording, and computer simulations
C
Comparator
Phasic versus tonic neurones
O
Outcome
Firing properties and underlying potassium currents (M-current, A-current, D2-current)surrogate

Differential expression of the M-current accounts for the distinct firing properties of phasic and tonic rat sympathetic neurones.

Cite This Study

Wang et al. (1995) studied this question.

synapsesocial.com/papers/6a82b3f7abc87fc4bf1e180fhttps://doi.org/10.1113/jphysiol.1995.sp020732
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Also Consider

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  4. 4Development of dendritic calcium currents in ganglion cells of the rat lower lumbar sympathetic chain.1986 · 39 citations
  5. 5An intracellular investigation of cat vesical pelvic ganglia1980 · 60 citations