Single voltage‐gated K+ channels and their functions in small dorsal root ganglion neurones of rat.

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Population

Small dorsal root ganglion (DRG) neurones in 150 microns thin slices of new-born rat DRG

Design

Preclinical

Authors

Discussion

Informs models of sensory neuron excitability in neonates; leaves open translation to adult pain or human therapeutics.

Population

Small dorsal root ganglion (DRG) neurones in 150 microns thin slices of new-born rat DRG

Intervention

Application of external tetraethylammonium (TEA) (1 and 5 mM) and patch-clamp recording

Outcome

Single-channel conductance, kinetics, and sensitivity to external tetraethylammonium (TEA) of voltage-activated K+ channelssurrogate

This study identifies five distinct types of voltage-gated K+ channels in small DRG neurones of new-born rats that regulate neuronal excitability.

Safronov et al. (1996) studied this question.

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