Key result
Voltage-independent Na+-activated K+ channels in rat motoneurones require high internal Na+ to drive slow after-hyperpolarization.
KNa channels in rat motoneurones are activated by local accumulation of internal Na+ during trains of action potentials, contributing to a slow after-hyperpolarization that reduces membrane excitability.
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Rat motoneuron data warrant no clinical changes; leaves open KNa channel roles in human motoneuron excitability.
Safronov et al. (1996) studied this question. Na(+)-activated K+ (KNa) channels was evaluated on Channel conductance and action potential properties. Na+-activated K+ channels in rat motoneurones are voltage-independent, require high internal Na+ for activation, and contribute to a slow after-hyperpolarization following action potential trains.
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