Gating and conductance properties of a human delayed rectifier K+ channel expressed in frog oocytes.

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Population

Xenopus oocytes expressing the human delayed rectifier K+ channel h-DRK1

Design

Preclinical

Authors

Discussion

No direct clinical implications; leaves open h-DRK1 contribution to native human cardiac currents.

Population

Xenopus oocytes expressing the human delayed rectifier K+ channel h-DRK1

Intervention

Electrophysiological characterization using patch-clamp techniques (micropatches, macropatches, giant patches, or whole oocytes)

Outcome

Gating and conductance properties of h-DRK1surrogate

The human delayed rectifier K+ channel h-DRK1 exhibits outward rectification and complex activation kinetics involving two different components.

Benndorf et al. (1994) studied this question.

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