Population
Xenopus oocytes expressing rat brain DRK1 (Kv2.1) cRNA
Comparison
Internal Mg2+ or Na+ ions introduced into bath… vs Solutions containing no Mg2+ or Na+ ions
Design
Preclinical
Authors
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Cation block induces inward rectification in DRK1 channels; extends biophysics models but leaves open relevance to native cardiac currents.
Inward going rectification resulting from voltage-dependent block by internal cations can be observed with normally outwardly rectifying DRK1 channels.
Lopatin et al. (1994) studied this question.
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