Population
ROMK1 inward-rectifier K+ channel
Design
Preclinical
Authors
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Suggests K+-dependent tuning of ROMK1 blockers in animal models; leaves open any clinical relevance for human channelopathies or therapies.
This basic science study demonstrates that inward rectification in ROMK1 channels involves energetic coupling between blocking ions and permeating K+ ions.
Spassova et al. (1998) studied this question.
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