Key result
Depolarizing voltage steps activated outward directed single-channel K+ currents (15-20 pS) in cultured rat hippocampal neurons, likely underlying the TEA-sensitive voltage-dependent K+ current.
Population
Dissociated embryonic rat hippocampal neurons grown in cell culture
Design
Preclinical
Authors
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Should not inform clinical decisions from rat neuronal models; leaves open cardiac relevance of these K+ currents.
This study characterizes the single-channel properties of a slowly activating, TEA-sensitive voltage-dependent K+ current in cultured rat hippocampal neurons.
Michael A. Rogawski (1986) studied this question. Depolarizing voltage steps was evaluated on Single-channel currents and channel opening probability. Depolarizing voltage steps activated outward directed single-channel K+ currents (15-20 pS) in cultured rat hippocampal neurons, likely underlying the TEA-sensitive voltage-dependent K+ current.
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