January 1, 1981Japanese Circulation Journal-english EditionOpen Access

Effects of acidosis on the excitation-contraction coupling system of cardiac muscle.

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Population

Isolated cardiac sarcoplasmic reticulum (SR) and myofibrils

Comparison

Acidosis (pH 6.4-6.6) vs Normal pH (pH 7.0)

Design

Preclinical

Authors

EOEiichiro OkabeMinistry of Education, Culture, Sports, Science and Technology MHMichael L. HessVirginia Commonwealth University

Discussion

Member takes

Overview

Hypothesis-generating for SR calcium uncoupling in ischemia; leaves open contribution to human ischemic contracture.

Structured PICO

Population

Isolated cardiac sarcoplasmic reticulum (SR) and myofibrils

Intervention

Acidosis (pH 6.4-6.6)

Comparator

Normal pH (pH 7.0)

Outcome

Calcium uptake velocity and ATPase activitysurrogate

Acidosis (pH 6.4-6.6) significantly uncouples calcium transport from ATP hydrolysis in cardiac SR and alters myofibrillar ATPase activity, potentially mediating contracture in ischemic myocardium.

Cite This Study

Okabe et al. (1981) studied this question.

synapsesocial.com/papers/6a858e567fcf0fdb395e239b https://doi.org/10.1253/jcj.45.1291

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January 1, 1981Japanese Circulation Journal-english EditionOpen Access

Effects of acidosis on the excitation-contraction coupling system of cardiac muscle.

View Full Paper

Ask AI

Bookmark

Population

Isolated cardiac sarcoplasmic reticulum (SR) and myofibrils

Comparison

Acidosis (pH 6.4-6.6) vs Normal pH (pH 7.0)

Design

Preclinical

Authors

EOEiichiro OkabeMinistry of Education, Culture, Sports, Science and Technology MHMichael L. HessVirginia Commonwealth University

Discussion

Member takes

Overview

Hypothesis-generating for SR calcium uncoupling in ischemia; leaves open contribution to human ischemic contracture.

Structured PICO

Population

Isolated cardiac sarcoplasmic reticulum (SR) and myofibrils

Intervention

Acidosis (pH 6.4-6.6)

Comparator

Normal pH (pH 7.0)

Outcome

Calcium uptake velocity and ATPase activitysurrogate

Acidosis (pH 6.4-6.6) significantly uncouples calcium transport from ATP hydrolysis in cardiac SR and alters myofibrillar ATPase activity, potentially mediating contracture in ischemic myocardium.

Cite This Study

Okabe et al. (1981) studied this question.

synapsesocial.com/papers/6a858e567fcf0fdb395e239b https://doi.org/10.1253/jcj.45.1291

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