Why the study?
Does lowering pH and adding phosphate alter Ca2+ release from the sarcoplasmic reticulum in rat ventricular trabeculae?
Population
Rat ventricular trabeculae permeabilised with saponin
Comparison
Alteration of pH and addition of phosphate vs Optimal pH (7.1 or 7.4) and absence of phosphate
Design
Preclinical
Authors
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Acidosis may impair contractility via direct SR effects; hypothesis-generating for in vivo or clinical relevance.
Does lowering pH and adding phosphate alter Ca2+ release from the sarcoplasmic reticulum in rat ventricular trabeculae?
Acidosis directly inhibits the SR Ca2+ release channel and Ca2+ accumulation independently of phosphate, contributing to the negative inotropic actions of intracellular acidosis in cardiac muscle.
Jonathan C. Kentish (1997) studied this question.
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