Key result
Acidosis increased the likelihood of spontaneous sarcoplasmic reticulum Ca2+ release in rat myocardium, causing spontaneous action potentials, increased resting tension, and reduced twitch tension.
Population
Rat myocardium (unstimulated and regularly stimulated rat papillary muscles, and single myocytes)
Comparison
Acidosis vs Baseline conditions (normal pH)
Design
Preclinical
Authors
Loading...
Acidosis may promote triggered activity in ischemic myocardium; leaves open human relevance and clinical implications.
Acidosis facilitates spontaneous sarcoplasmic reticulum Ca2+ release in rat myocardium, leading to spontaneous action potentials and altered tension.
Orchard et al. (1987) studied Rat myocardium. Acidosis vs. Normal [CO2] (5%) was evaluated on Spontaneous sarcoplasmic reticulum (SR) Ca2+ release and functional sequelae. Acidosis increased the likelihood of spontaneous sarcoplasmic reticulum Ca2+ release in rat myocardium, causing spontaneous action potentials, increased resting tension, and reduced twitch tension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: