Population
Isolated rat ventricular myocytes
Comparison
Acidosis produced by application of the weak… vs Control conditions (prior to butyrate application)
Design
Preclinical
Follow-up
2 minutes
Authors
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May caution against assuming persistent systolic impairment in acidotic myocardium; leaves open translation to human ischemia or HF models.
Acidosis-induced recovery of systolic Ca2+ transients in rat ventricular myocytes is driven by increased sarcoplasmic reticulum calcium content resulting from reduced cellular Ca2+ efflux.
Choi et al. (2000) studied this question.
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