Population
Adult rat left ventricular myocytes (n=16 for pHi measurement) and mitochondrial suspensions
Comparison
Hypercarbic acidosis or lactic acid addition vs Normocarbic conditions (5% CO2)
Design
Preclinical
Authors
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Does not support clinical changes in acidosis management; leaves open whether intracellular buffers drive Ca2+ rises in intact or contracting myocardium.
Acidosis increases resting cytosolic and mitochondrial Ca2+ in mammalian myocardium, with intracellular buffers acting as the likely Ca2+ sources in quiescent cells.
Gambassi et al. (1993) studied this question.
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