Population
Skinned cardiac muscle and fast-twitch skeletal muscle fibers (myocytes)
Comparison
Acidosis (acid pH) and troponin C exchange vs Normal pH / skeletal vs cardiac troponin C
Design
Preclinical
Authors
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Shifts mechanistic focus to troponin regulatory interactions in acidosis; hypothesis-generating, requires human validation before clinical consideration.
Acidosis decreases Ca2+ sensitivity in cardiac muscle by modulating protein-protein interactions in the regulatory complex rather than through direct H+-Ca2+ competition on troponin C.
Gulati et al. (1989) studied this question.
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