Why the study?
Does the expression of skeletal troponin C reduce contractile sensitivity to acidosis in cardiac myocytes?
Population
Permeabilized single cardiac myocytes from transgenic mice expressing fast skeletal troponin C and control…
Comparison
Expression of the fast skeletal isoform of… vs Expression of endogenous cardiac troponin C (cTnC)
Design
Preclinical
Authors
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Skeletal TnC attenuates myofilament acidosis sensitivity in cardiac myocytes; leaves open cTnC as a therapeutic target in ischemia.
Does the expression of skeletal troponin C reduce contractile sensitivity to acidosis in cardiac myocytes?
Expression of the fast skeletal isoform of troponin C in cardiac myocytes significantly reduces their contractile sensitivity to acidosis, identifying cTnC as a potential therapeutic target for ischemia-induced myocardial contractile dysfunction.
Metzger et al. (1993) studied this question.
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