Key result
Decreasing pH from 7.0 to 6.2 caused a greater suppression of tension and rightward shift in pCa50 in adult rat cardiac trabeculae compared with soleus fibers due to different TnI isoforms.
Population
Chemically skinned preparations of adult rat trabeculae and single soleus fibers, and troponin subunit…
Comparison
Acidic pH (decrease from 7.0 to 6.2) vs Neutral pH (7.0)
Design
Preclinical
Authors
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TnI isoform differences may drive cardiac acidosis sensitivity; hypothesis-generating for human myocardial pH effects.
Differential effects of acidic pH on tension generation and Ca2+ sensitivity between soleus fibers and cardiac trabeculae are driven by the presence of different isoforms of troponin I.
Wattanapermpool et al. (1995) studied this question. Acidic pH vs. pH 7.0 was evaluated on Ca(2+)-activation of force and pCa50 shift. Decreasing pH from 7.0 to 6.2 caused a greater suppression of tension and rightward shift in pCa50 in adult rat cardiac trabeculae compared with soleus fibers due to different TnI isoforms.
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