Population
Permeabilized single myofibers of fast-twitch skeletal muscle and skinned cardiotrabeculae of the rat
Comparison
Exchange of cardiac troponin C and troponin I… vs Endogenous cardiac proteins and pH 7 vs pH 6.2…
Design
Preclinical
Authors
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TnC isoform differences may heighten cardiac pH sensitivity; hypothesis-generating for isoform-targeted research, should not change practice.
The study demonstrates that the larger acidic pH-induced depression of Ca2+ sensitivity in cardiac versus skeletal muscle is partially mediated by differences in troponin C isoforms.
Ding et al. (1995) studied this question.
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