Key result
Metabolic acidosis induced comparable decrements in oxygen consumption (~35%) and cardiac function (~65%) in isolated perfused rat hearts, likely by inhibiting mitochondrial substrate utilization.
Population
Isolated perfused rat hearts and isolated cardiac mitochondria
Comparison
Metabolic acidosis vs Normal pH conditions
Design
Preclinical
Authors
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Metabolic acidosis effects in isolated rat hearts warrant caution against clinical extrapolation; leaves open relevance to intact human cardiac energetics.
Metabolic acidosis impairs energy production in the isolated perfused heart by inhibiting mitochondrial substrate utilization secondarily, rather than through a direct effect of acidosis on mitochondria.
Süleymanlar et al. (1992) studied Metabolic acidosis. Metabolic acidosis vs. Normal pH was evaluated on Energy metabolism (oxygen consumption, cardiac function, high-energy phosphates). Metabolic acidosis induced comparable decrements in oxygen consumption (~35%) and cardiac function (~65%) in isolated perfused rat hearts, likely by inhibiting mitochondrial substrate utilization.
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