Key result
Acute respiratory acidosis induced more pronounced negative inotropic effects than metabolic acidosis in rat myocardium (45% vs 63% of baseline in isotonic conditions, P<0.001).
Why the study?
Does acute respiratory versus metabolic acidosis differentially affect inotropy, lusitropy, and adrenoceptor stimulation responses in rat myocardium?
Population
Isolated rat left ventricular papillary muscle (n=8 per group) and isolated rat cardiomyocytes
Comparison
Acute respiratory and metabolic acidosis with α… vs Comparison between respiratory and metabolic…
Design
Preclinical
Authors
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Respiratory acidosis may depress rat myocardial contractility more than metabolic acidosis; leaves open translation to human myocardium and β-adrenergic responses.
Does acute respiratory versus metabolic acidosis differentially affect inotropy, lusitropy, and adrenoceptor stimulation responses in rat myocardium?
Absolute Event Rate: 45% vs 63%
p-value: p=<0.001
Acute metabolic and respiratory acidosis induce different myocardial effects, with only metabolic acidosis impairing the positive inotropic effect of β-adrenergic stimulation.
Biais et al. (2012) studied Acute respiratory and metabolic acidosis. Acute respiratory acidosis vs. Acute metabolic acidosis was evaluated on Negative inotropic effects in isotonic conditions (% of baseline) (p=<0.001). Acute respiratory acidosis induced more pronounced negative inotropic effects than metabolic acidosis in rat myocardium (45% vs 63% of baseline in isotonic conditions, P<0.001).
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