Why the study?
Does Sotalol alter intracellular pH in rat cardiac and skeletal muscle during acid-base disturbances?
Population
Rat model subjected to varying extracellular acid-base states
Comparison
Beta-adrenoreceptor antagonist Sotalol (MJ 1999) vs Unblocked animals (no beta-blocker)
Design
Preclinical
Follow-up
2 hours
Authors
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Beta-blockade may exacerbate intracellular acidosis during metabolic stress in rats; leaves open effects in humans or on clinical outcomes.
Does Sotalol alter intracellular pH in rat cardiac and skeletal muscle during acid-base disturbances?
Catecholamine release during acidosis attenuates the drop in intracellular pH and increases the effective buffer value of cardiac and skeletal muscle, an effect blocked by Sotalol.
Clancy et al. (1976) studied this question.
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