December 1, 1992The Journal of PhysiologyOpen Access

Effect of catecholamines on intracellular pH in sheep cardiac Purkinje fibres.

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Population

Resting sheep cardiac Purkinje fibres

Design

Preclinical

Authors

HGHuicai GuoHebei Medical University JWJ. Andrew WasserstromElectrophysiology JRJames E. RosenthalSwiss Center for Electronics and Microtechnology (Switzerland)

Discussion

Member takes

Implication

Does not support changes to beta-agonist use in patients; leaves open translation of Purkinje fibre acidification to human myocardium.

Structured PICO

Population

Resting sheep cardiac Purkinje fibres

Intervention

Adrenaline (5.0 x 10^-6 M), isoprenaline (5.0 x 10^-6 M), phenylephrine (up to 200 microM), and forskolin (7.5-10 x 10^-5 M)

Outcome

Intracellular pH (pHi) and transmembrane potentialsurrogate

In sheep cardiac Purkinje fibres, beta-adrenergic stimulation causes intracellular acidification and depolarization, likely mediated by increased cyclic AMP, partial inhibition of Na(+)-H+ exchange, and stimulation of glycolysis.

Cite This Study

Guo et al. (1992) studied this question.

synapsesocial.com/papers/6a82a28b129689dedc13339a https://doi.org/10.1113/jphysiol.1992.sp019418

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Effect of catecholamines on intracellular pH in sheep cardiac Purkinje fibres.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of catecholamines on intracellular pH in sheep cardiac Purkinje fibres.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider