Population
Isolated sheep cardiac Purkinje fibres
Comparison
Electrical stimulation in the presence of… vs Control conditions without inhibitors or ion…
Design
Preclinical
Authors
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Glycolysis-linked acidosis in Purkinje fibres merits mechanistic follow-up; leaves open relevance to human arrhythmias or therapy.
Rate-dependent intracellular acidosis in sheep cardiac Purkinje fibres is primarily driven by glycolysis following increased contraction, rather than by Na+-H+ exchange or aerobic metabolism.
Bountra et al. (1988) studied this question.
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