Effects of changes of intracellular pH on contraction in sheep cardiac Purkinje fibers.

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Population

Sheep cardiac Purkinje fibers

Comparison

Alteration of intracellular pH using NH4Cl… vs Baseline conditions

Design

Preclinical

Authors

Discussion

Hypothesis-generating for pH-sensitive contractility; leaves open human translation and clinical relevance.

Population

Sheep cardiac Purkinje fibers

Intervention

Alteration of intracellular pH using NH4Cl (5-20 mM), extracellular pH changes, or strophanthidin (10 microM)

Comparator

Baseline conditions (nominally CO2/HCO3 free solutions buffered with Tris)

Outcome

Twitch tension/contraction forcesurrogate

Cardiac contraction is directly sensitive to changes in intracellular pH, which can modify the contractile response to inotropic agents.

Vaughan‐Jones et al. (1987) studied this question.

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