Extracellular pH-induced changes in contractile state in cultured heart cells correlate with altered transsarcolemmal calcium movements, whereas intracellular pH changes appear to involve altered intracellular calcium handling or myofibril sensitivity.
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Warrants caution against clinical extrapolation from cultured myocytes; extends mechanistic links between extracellular pH and calcium handling in cardiomyocytes.
Kim et al. (1987) studied this question.
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