Population
Resting cat papillary muscles and resting ventricular myocytes (cat, guinea pig)
Design
Preclinical
Authors
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pHi effects on myocyte resting tension may influence diastolic tone; leaves open translation to intact hearts or patients.
Intracellular alkalosis increases resting tension and decreases cell length in ventricular muscle and myocytes, suggesting factors beyond myofilament Ca2+ sensitivity contribute to the resting contractile response.
Spitzer et al. (1992) studied this question.
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