Effect of metabolic inhibitors and second messengers upon Na(+)‐H+ exchange in the sheep cardiac Purkinje fibre.

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Population

Sheep cardiac Purkinje fibres

Comparison

Metabolic inhibitors and second… vs Control conditions

Design

Preclinical

Authors

Discussion

Hypothesis-generating for metabolic and cAMP control of cardiac NHE; leaves open translation to human ischemia or HF models.

Population

Sheep cardiac Purkinje fibres

Intervention

Metabolic inhibitors (2-deoxyglucose, cyanide) and second messengers/modulators (IBMX, sodium nitroprusside, trifluorperazine, TPA)

Comparator

Control conditions (e.g., glucose-containing solution, no IBMX)

Outcome

Intracellular pH (pHi) recovery from an intracellular acid load and rate of rise of intracellular Na+ activity (aiNa)surrogate

In sheep cardiac Purkinje fibres, Na+-H+ exchange is downregulated by inhibition of glycolysis or elevation of cAMP, but not by oxidative inhibition.

Wu et al. (1994) studied this question.

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