Population
Sheep cardiac Purkinje fibres
Comparison
Reducing extracellular pH and internal acid load… vs Normal or varying extracellular pH levels
Design
Preclinical
Authors
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Extracellular pH may modulate cardiac Na-H exchange; extends cellular mechanisms in Purkinje fibers but leaves human translation open.
Reducing extracellular pH directly inhibits Na+-H+ exchange in sheep cardiac Purkinje fibres, independent of the transmembrane H+ gradient.
Vaughan‐Jones et al. (1990) studied this question.
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