Why the study?
Does metabolic acidosis affect digitalis tolerance, myocardial contractility, and ventricular fibrillation threshold compared to respiratory acidosis?
Population
Experimental model (heart)
Comparison
Metabolic acidosis induced by lactic acid infusion vs Respiratory acidosis and control
Design
Preclinical
Authors
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Metabolic acidosis may impair digitalis tolerance and contractility more than respiratory acidosis in animals; leaves open clinical translation.
Does metabolic acidosis affect digitalis tolerance, myocardial contractility, and ventricular fibrillation threshold compared to respiratory acidosis?
Metabolic acidosis, but not respiratory acidosis, significantly impairs cardiac contractility and increases susceptibility to arrhythmias and digitalis toxicity in an experimental model.
Nonoyama et al. (1970) studied this question.