Key result
In isolated rat hearts, extramyocardial acidosis below pH 7.1 impaired resuscitability after ventricular fibrillation, with no hearts recovering at a pH below 6.5.
Population
31 isolated, perfused hearts from male Sprague-Dawley rats
Comparison
Perfusion with HEPES buffered solution titrated… vs Perfusion with HEPES buffered solution at normal…
Design
Preclinical, Hearts were allocated randomly to each group
Follow-up
30 minutes of reperfusion
Authors
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Does not support changes to clinical pH targets in resuscitation; leaves open translation to human cardiac arrest outcomes.
RCT (n=31)
Randomly allocated
Extramyocardial acidosis below pH 7.1 significantly decreases cardiac performance and resuscitability after ventricular fibrillation in an isolated rat heart model.
Morimoto et al. (1996) conducted an RCT in Cardiac arrest and ventricular fibrillation (n=31). Extramyocardial acidosis (perfusion solutions titrated to pH 6.2, 6.5, 6.8, or 7.1) vs. pH 7.4 was evaluated on Cardiac performance and resuscitability (recovery of left ventricular developed pressure at > 35 mm Hg). In isolated rat hearts, extramyocardial acidosis below pH 7.1 impaired resuscitability after ventricular fibrillation, with no hearts recovering at a pH below 6.5.
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