What question did this study set out to answer?

To investigate whether severe hypercarbic acidosis, independent of arterial oxygenation, directly impairs the success of cardiac resuscitation following cardiac arrest.

September 1, 1991Critical Care Medicine

Hypercarbic acidosis reduces cardiac resuscitability

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Authors

IPIrene von PlantaDie Johanniter MWMax Harry WeilCross-Cutting Cardiology MPMartin von PlantaUniversity Hospital of Basel

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Implication

Controlled laboratory study reveals that severe hypercarbic acidosis prevents successful defibrillation in rats, indicating that excess carbon dioxide directly undermines cardiac resuscitation.

Key Points

To investigate whether severe hypercarbic acidosis, independent of arterial oxygenation, directly impairs the success of cardiac resuscitation following cardiac arrest.
Three groups of Sprague-Dawley rats (n=6 per group) were ventilated with inspired carbon dioxide fractions (FICO2) of 0.0, 0.3, or 0.5, while inspired oxygen was held constant at 0.5.
Ventricular fibrillation was maintained for 4 minutes followed by 2 minutes of mechanical chest compressions before attempting transthoracic defibrillation; a control group (n=7) received FICO2 of 0.5 without cardiac arrest.
Resuscitation was achieved in 100% of animals ventilated with FICO2 of 0.0 (6 of 6) and FICO2 of 0.3 (6 of 6), compared with 0% of animals (0 of 6) ventilated with FICO2 of 0.5 (p < .001).
Animals failing resuscitation under FICO2 of 0.5 developed severe acidemia with aortic pH < 6.67 and aortic PCO2 > 200 torr (> 26.7 kPa), whereas non-arrest control animals ventilated with FICO2 of 0.5 showed no adverse effects.

Cite This Study

Planta et al. (1991) studied this question.

synapsesocial.com/papers/6a96c59cdbc641e6a0a6dd0e https://doi.org/10.1097/00003246-199109000-00014

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Implication

Controlled laboratory study reveals that severe hypercarbic acidosis prevents successful defibrillation in rats, indicating that excess carbon dioxide directly undermines cardiac resuscitation.

Hypercarbic acidosis reduces cardiac resuscitability

Discussion

Member takes

Implication

Key Points

Cite This Study

Hypercarbic acidosis reduces cardiac resuscitability

Discussion

Member takes

Implication

Key Points

Cite This Study

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