Key result
Pulmonary gas exchange during experimental CPR appears to be independent of alkaline buffer therapy, with blood flow rather than ventilation being the limiting factor for CO2 disposal.
Why the study?
Does alkaline buffer therapy (sodium bicarbonate or tris buffer) improve pulmonary gas exchange during CPR in a piglet model of ventricular fibrillation?
Population
19 anaesthetized piglets with induced ventricular fibrillation undergoing cardiopulmonary resuscitation (CPR)
Comparison
50 mmol of sodium bicarbonate or tris buffer… vs Normal saline (n=6) infused during CPR
Design
Preclinical
Follow-up
10 minutes
Authors
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Alkaline buffers should not be used to target gas exchange in CPR; leaves open whether blood flow optimization improves outcomes in clinical resuscitation.
Does alkaline buffer therapy (sodium bicarbonate or tris buffer) improve pulmonary gas exchange during CPR in a piglet model of ventricular fibrillation?
In a piglet model of CPR, pulmonary gas exchange is limited by blood flow rather than ventilation and is not improved by alkaline buffer therapy.
Wiklund et al. (1992) studied Ventricular fibrillation and cardiopulmonary resuscitation (n=19). Sodium bicarbonate or tris buffer mixture vs. Normal saline was evaluated on Pulmonary gas exchange and CO2 disposal. Pulmonary gas exchange during experimental CPR appears to be independent of alkaline buffer therapy, with blood flow rather than ventilation being the limiting factor for CO2 disposal.
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