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April 1, 1989Cardiovascular Research

End tidal carbon dioxide as an haemodynamic determinant of cardiopulmonary resuscitation in the rat

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Key result

PETCO2 > 9 mm Hg during precordial compression predicted successful resuscitation in rats, with 87.5% success compared to 0% when PETCO2 was < 9 mm Hg.

Why the study?

Does end-tidal PCO2 predict successful resuscitation and correlate with perfusion pressures during CPR in a rat model?

Population

14 mechanically ventilated Sprague-Dawley rats subjected to ventricular fibrillation and closed chest…

Design

Preclinical

Follow-up

60 min post-resuscitation

Authors

MPMartin von PlantaIPIrene von PlantaMWMax Harry Weil

Discussion

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Overview

Supports PETCO2 monitoring in rat CPR models; leaves open translation to clinical resuscitation.

Structured PICO

Does end-tidal PCO2 predict successful resuscitation and correlate with perfusion pressures during CPR in a rat model?

P
Population
14 mechanically ventilated Sprague-Dawley rats undergoing induced ventricular fibrillation and closed chest resuscitation.
E
Exposure
End-tidal PCO2 (PETCO2) monitoring during precordial compression
O
Outcome
Success of defibrillation with return of spontaneous circulation and correlation with aortic and coronary perfusion pressuressurrogate

Main Result

Absolute Event Rate: 87.5% vs 0%

PETCO2 serves as a reliable non-invasive monitor of coronary perfusion effectiveness and a predictor of successful resuscitation during CPR in a rat model.

Cite This Study

Planta et al. (1989) studied Cardiac arrest (n=14). PETCO2 > 9 mm Hg during precordial compression vs. PETCO2 < 9 mm Hg was evaluated on Successful resuscitation with return of spontaneous circulation. PETCO2 > 9 mm Hg during precordial compression predicted successful resuscitation in rats, with 87.5% success compared to 0% when PETCO2 was < 9 mm Hg.

synapsesocial.com/papers/6a9ffbf683b4417cc5efda0fhttps://doi.org/10.1093/cvr/23.4.364
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Volumetric capnography and return of spontaneous circulation in an experimental model of pediatric asphyxial cardiac arrest2023 · 1 citations
  2. 2Capnography during cardiac resuscitation: a clue on mechanisms and a guide to interventions.2003 · 18 citations
  3. 3Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation1993 · 104 citations
  4. 4Correlation of end tidal carbon dioxide, amplitude spectrum area, and coronary perfusion pressure in a porcine model of cardiac arrest2017 · 19 citations
  5. 5Gas exchange as monitored in mixed venous and arterial blood during experimental cardiopulmonary resuscitation1992 · 16 citations