Why the study?
Do buffer agents (sodium bicarbonate or Carbicarb) improve intramyocardial pH and cardiac resuscitability in a porcine model of ventricular fibrillation?
Population
29 pigs with electrically induced ventricular fibrillation (VF) undergoing cardiac resuscitation
Comparison
Sodium bicarbonate or Carbicarb infused into the… vs Hypertonic sodium chloride (control solution)
Design
Preclinical
Follow-up
11 minutes
Authors
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Buffers ineffective in porcine VF model; leaves open clinical translation to human resuscitation.
Do buffer agents (sodium bicarbonate or Carbicarb) improve intramyocardial pH and cardiac resuscitability in a porcine model of ventricular fibrillation?
Administration of buffer agents during cardiac resuscitation does not reverse intramyocardial acidosis or improve resuscitability in a porcine model of ventricular fibrillation.
Kette et al. (1990) studied this question.
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