Why the study?
Do tromethamine or sodium bicarbonate buffers improve cardiac resuscitability and survival in a porcine model of cardiac arrest compared to placebo?
Population
30 domestic pigs using a well-established model of electrically induced cardiac arrest and resuscitation
Comparison
Iso-osmolal solutions of tris-hydroxymethyl-amino… vs Sodium chloride placebo
Design
Preclinical
Authors
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No benefit from buffers in porcine arrest; leaves open human translation while cautioning against tromethamine vasodilation.
Do tromethamine or sodium bicarbonate buffers improve cardiac resuscitability and survival in a porcine model of cardiac arrest compared to placebo?
In a porcine model of cardiac arrest, neither tromethamine nor sodium bicarbonate improved resuscitability or survival compared to placebo, and tromethamine caused detrimental vasodilation.
Planta et al. (1988) studied this question.
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