Why the study?
Does high-dose sodium bicarbonate improve the vasopressor effects of epinephrine during CPR in a canine model?
Population
12 mongrel dogs with a previous episode of CPR, undergoing 3 minutes of ventricular fibrillation followed by…
Comparison
Sodium bicarbonate 3 mEq/kg infused over 2… vs Normal saline 3 ml/kg infused over 2 minutes…
Design
Preclinical, randomized, blinded
Follow-up
7 minutes of CPR
Authors
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Does not support bicarbonate to potentiate epinephrine in CPR; leaves open translation to clinical practice.
Does high-dose sodium bicarbonate improve the vasopressor effects of epinephrine during CPR in a canine model?
High-dose sodium bicarbonate administration does not improve the vasopressor effects of epinephrine during CPR in a canine model.
Bleske et al. (1995) studied this question.
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