August 1, 1988Critical Care Medicine
Effects of Sodium Bicarbonate in Canine Hemorrhagic Shock
Why the study?
Does sodium bicarbonate improve hemodynamics, blood gases, or lactate levels in a canine model of hemorrhagic shock?
Population
13 dogs, anesthetized, paralyzed, mechanically ventilated, and hemodynamically monitored, with induced…
Comparison
Sodium bicarbonate vs NaCl infusion
Design
Preclinical, randomized into two groups
Follow-up
2.5 hours
Authors
Discussion
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Implication
Challenges bicarbonate in hemorrhagic shock models; leaves open translation to human lactic acidosis.
Structured PICO
Does sodium bicarbonate improve hemodynamics, blood gases, or lactate levels in a canine model of hemorrhagic shock?
P
Population
13 dogs, anesthetized, paralyzed, mechanically ventilated, and hemodynamically monitored, with induced hemorrhagic shock (maintained at mean arterial pressure of 40 to 45 mm Hg for 2.5 h).
I
Intervention
Sodium bicarbonate (1 mEq/kg followed by a continuous infusion of 2.5 mEq/kg.h for 2.5 h)
C
Comparator
NaCl infusion
O
Outcome
Hemodynamics, arterial and venous blood gases, respiratory gases, and blood lactate levelssurrogate
Sodium bicarbonate administration in a canine model of hemorrhagic shock does not improve hemodynamics and significantly increases blood lactate levels, suggesting limited usefulness in treating lactic acidosis.
Cite This Study
Iberti et al. (1988) studied this question.