Why the study?
Does sodium bicarbonate compared to sodium carbonate improve pH without exacerbating hypercarbia in mixed venous blood during steady-state and low-perfusion conditions in dogs?
Population
15 adult mongrel dogs of both sexes subjected to hemorrhagic shock
Comparison
Sodium bicarbonate 1 mEq/kg infused over 5 min… vs Sodium carbonate 1 mEq/kg infused over 5 min…
Design
Preclinical
Follow-up
15 minutes after buffer infusion
Key result
Sodium bicarbonate infusion had no deleterious effect on the pH or Pco2 of mixed, portal, or hepatic venous blood in steady and low perfusion states compared to sodium carbonate.
Authors
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Supports bicarbonate safety vs carbonate in canine low-perfusion states without hypercarbia; leaves open human translation and lactate effects.
Does sodium bicarbonate compared to sodium carbonate improve pH without exacerbating hypercarbia in mixed venous blood during steady-state and low-perfusion conditions in dogs?
p-value: p=<0.05
Sodium bicarbonate can be safely used in disturbed circulatory states without causing deleterious venous hypercarbia, and it increases hepatic lactate uptake compared to sodium carbonate.
Kon et al. (1995) studied Hemorrhagic shock (n=15). Sodium bicarbonate vs. Sodium carbonate was evaluated on pH in mixed venous blood at 1 minute after buffer infusion (p=<0.05). Sodium bicarbonate infusion had no deleterious effect on the pH or Pco2 of mixed, portal, or hepatic venous blood in steady and low perfusion states compared to sodium carbonate.