January 2, 1994Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyOpen Access

An Alternative Sodium Bicarbonate Regimen During Cardiac Arrest and Cardiopulmonary Resuscitation in a Canine Model

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Ventricular fibrillation and cardiopulmonary resuscitation (n=13). Intervention: Frequent, early bolus administration of low-dose sodium bicarbonate vs. Normal saline and standard bolus doses of sodium bicarbonate. Primary outcome: Arterial partial pressures of carbon dioxide (pCO2) and arterial pH at 18 minutes of fibrillation.

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Key result

Frequent low-dose sodium bicarbonate during CPR in dogs produced higher arterial pCO2 (42 vs 29 and 35 torr) and arterial alkalemia (pH 7.46) at 18 minutes than saline or standard bicarbonate.

Why the study?

Does frequent, early bolus administration of low-dose sodium bicarbonate affect blood gas values during ventricular fibrillation and CPR in a canine model?

Population

13 mongrel dogs undergoing 3 minutes of ventricular fibrillation followed by 15 minutes of cardiopulmonary…

Comparison

Sodium bicarbonate 0.5 mEq/kg at 5, 10, and 15… vs Standard bolus doses of NaHCO3 or normal saline

Design

Preclinical, Randomly assigned

Follow-up

18 minutes of fibrillation

Authors

BBBarry E. BleskeUniversity of New Mexico TRTed L. RiceUniversity of Pittsburgh EWEric W. WarrenSt. Finbarr's Hospital

Discussion

Member takes

Implication

Frequent low-dose NaHCO3 may produce detrimental alkalemia during CPR; leaves open optimal buffering strategies for clinical trials.

Study Design

Type

RCT (n=13)

Randomization

randomly assigned

Structured PICO

Does frequent, early bolus administration of low-dose sodium bicarbonate affect blood gas values during ventricular fibrillation and CPR in a canine model?

Population

13 mongrel dogs undergoing 18 experiments of ventricular fibrillation and cardiopulmonary resuscitation.

Intervention

Sodium bicarbonate (NaHCO3) 0.5 mEq/kg at 5, 10, and 15 minutes of ventricular fibrillation (SB)

Comparator

Standard bolus doses of NaHCO3 (1 mEq/kg at 5 minutes and 0.5 mEq/kg at 15 minutes) (B) or normal saline (0.9% NaCl 1 ml/kg at 5 minutes and 0.5 ml/kg at 15 minutes) (P)

Outcome

Arterial and venous blood gas values (pCO2 and pH) sampled at 4, 8, 13, and 18 minutes of fibrillationsurrogate

In a canine model of cardiac arrest, frequent early low-dose sodium bicarbonate during CPR resulted in higher arterial pCO2 and arterial alkalemia compared to standard dosing or saline.

Cite This Study

Bleske et al. (1994) conducted an RCT in Ventricular fibrillation and cardiopulmonary resuscitation (n=13). Frequent, early bolus administration of low-dose sodium bicarbonate vs. Normal saline and standard bolus doses of sodium bicarbonate was evaluated on Arterial partial pressures of carbon dioxide (pCO2) and arterial pH at 18 minutes of fibrillation. Frequent low-dose sodium bicarbonate during CPR in dogs produced higher arterial pCO2 (42 vs 29 and 35 torr) and arterial alkalemia (pH 7.46) at 18 minutes than saline or standard bicarbonate.

synapsesocial.com/papers/6a6b3d91547974b2dbf43de8 https://doi.org/10.1002/j.1875-9114.1994.tb02792.x

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An Alternative Sodium Bicarbonate Regimen During Cardiac Arrest and Cardiopulmonary Resuscitation in a Canine Model

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

An Alternative Sodium Bicarbonate Regimen During Cardiac Arrest and Cardiopulmonary Resuscitation in a Canine Model

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider