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June 20, 2026Infectious Disorders - Drug Targets

The Effective Dosing Schedule of Sodium Bicarbonate for Improving pH inPatients with Metabolic Acidosis

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Authors

KBKarman Preet Kaur BenipalKMKrishna MurtyDKDharmendra Kumar

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Overview

Randomized trial examines pH improvement in ICU patients with metabolic acidosis, suggesting optimal dosing regimens.

Key Points

  • This study aims to compare the effectiveness of different sodium bicarbonate dosing regimens in treating metabolic acidosis.
  • Prospective randomized interventional study with 60 ICU patients having metabolic acidosis (pH < 7.25).
  • Patients were divided into three groups: Group A received total bicarbonate dose, Group B received 15% bolus and 85% infusion, Group C received 30% bolus and 70% infusion.
  • pH and EtCO2 were measured at multiple time points over 48 hours.
  • Blood pH significantly improved in all groups with Group C showing the quickest correction by 16 hours.
  • Group B demonstrated the most consistent pH correction at 24 and 48 hours with less variation.
  • Survival rates were slightly higher in Groups B and C (40%) compared to Group A (30%), but this difference was not statistically significant.

Cite This Study

Benipal et al. (2026) studied this question.

synapsesocial.com/papers/6a3631fbdb0793dc1a538a89https://doi.org/10.2174/0118715265459925260531193221
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sodium bicarbonate therapy in severe metabolic acidemia: an individual patient data meta-analysis of the BICAR-ICU and BICAR-ICU2 trials2026 · 2 citations
  2. 2Sodium Bicarbonate for Acute Metabolic Acidosis in Critically Ill Adults: A Meta-Analysis of Randomized Clinical Trials2026 · 1 citations
  3. 3Oral Sodium Bicarbonate vs. Use of Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis: A Randomized Controlled Trial2025 · 1 citations
  4. 4Severity of Metabolic Acidosis as a Determinant of Bicarbonate Requirements1973 · 110 citations
  5. 5Sodium bicarbonate for “metabolic acidosis”: an illustration of the Goodhart’s law2026