What question did this study set out to answer?

The aim is to evaluate the effects of sodium bicarbonate on critically ill patients with acute metabolic acidosis.

Sodium Bicarbonate for Acute Metabolic Acidosis in Critically Ill Adults: A Meta-Analysis of Randomized Clinical Trials

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Meta-analysis demonstrates sodium bicarbonate reduces renal replacement therapy in critically ill adults, suggesting possible mortality benefits.

The aim is to evaluate the effects of sodium bicarbonate on critically ill patients with acute metabolic acidosis.
Systematic search of databases for randomized controlled trials comparing sodium bicarbonate with placebo.
Inclusion of four trials with a total of 1,111 patients.
Performing Hartung-Knapp meta-analyses and Bayesian analyses for outcomes.
Sodium bicarbonate reduced renal replacement therapy use with a risk ratio (RR) of 0.69 (95% CI, 0.61-0.78).
Mortality showed a nonsignificant trend with an RR of 0.84 (95% CI, 0.55-1.30).
Bayesian analysis indicated a 90.4% probability of any mortality reduction alongside a 94.6% probability of reduced RRT use.

Chen et al. (2026) studied this question.

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Meta-analysis demonstrates sodium bicarbonate reduces renal replacement therapy in critically ill adults, suggesting possible mortality benefits.