What question did this study set out to answer?

To compare the efficacy of oral sodium bicarbonate supplementation versus increased dialysate bicarbonate concentration for correcting metabolic acidosis in hemodialysis patients over 16 weeks.

March 14, 2025Hemodialysis International

Oral Sodium Bicarbonate vs. Use of Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis: A Randomized Controlled Trial

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Authors

HAHoda Mahmoud Mohammad Abdulaziz ASAlaa Sabry MSMarwa Saleh

Discussion

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Overview

Randomized trial finds oral and higher dialysate bicarbonate yield similar serum levels in hemodialysis patients, indicating both strategies were insufficient to correct metabolic acidosis.

Key Points

To compare the efficacy of oral sodium bicarbonate supplementation versus increased dialysate bicarbonate concentration for correcting metabolic acidosis in hemodialysis patients over 16 weeks.
Single-center, open-label randomized controlled trial enrolling 75 adult hemodialysis patients with metabolic acidosis (serum bicarbonate < 22 mmol/L), with 66 completing the 16-week intervention.
Participants were randomly assigned (1:1:1) to standard dialysate (32 mM bicarbonate), increased dialysate bicarbonate (34 mM bicarbonate), or standard dialysate plus daily oral sodium bicarbonate (0.3–0.5 mmol/kg).
At 16 weeks, predialysis serum bicarbonate did not differ significantly among groups (p = 0.701), with mean levels of 20.1 (SD 2.16) mmol/L for standard dialysate, 20.5 (SD 2.04) mmol/L for increased dialysate, and 20.8 (SD 2.61) mmol/L for oral supplementation.
Predialysis serum bicarbonate increased significantly from baseline within the increased dialysate group (p = 0.010) and oral supplementation group (p = 0.021), but not in the standard dialysate group; neither intervention achieved the target level of ≥ 22 mmol/L.

Cite This Study

Abdulaziz et al. (2025) studied this question.

synapsesocial.com/papers/6a97687351c248f2dd31b9df https://doi.org/10.1111/hdi.13230

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March 14, 2025Hemodialysis International

Oral Sodium Bicarbonate vs. Use of Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis: A Randomized Controlled Trial

View Full Paper

Ask AI

Bookmark

Authors

HAHoda Mahmoud Mohammad Abdulaziz ASAlaa Sabry MSMarwa Saleh

Discussion

Member takes

Overview

Randomized trial finds oral and higher dialysate bicarbonate yield similar serum levels in hemodialysis patients, indicating both strategies were insufficient to correct metabolic acidosis.

Key Points

To compare the efficacy of oral sodium bicarbonate supplementation versus increased dialysate bicarbonate concentration for correcting metabolic acidosis in hemodialysis patients over 16 weeks.
Single-center, open-label randomized controlled trial enrolling 75 adult hemodialysis patients with metabolic acidosis (serum bicarbonate < 22 mmol/L), with 66 completing the 16-week intervention.
Participants were randomly assigned (1:1:1) to standard dialysate (32 mM bicarbonate), increased dialysate bicarbonate (34 mM bicarbonate), or standard dialysate plus daily oral sodium bicarbonate (0.3–0.5 mmol/kg).
At 16 weeks, predialysis serum bicarbonate did not differ significantly among groups (p = 0.701), with mean levels of 20.1 (SD 2.16) mmol/L for standard dialysate, 20.5 (SD 2.04) mmol/L for increased dialysate, and 20.8 (SD 2.61) mmol/L for oral supplementation.
Predialysis serum bicarbonate increased significantly from baseline within the increased dialysate group (p = 0.010) and oral supplementation group (p = 0.021), but not in the standard dialysate group; neither intervention achieved the target level of ≥ 22 mmol/L.

Cite This Study

Abdulaziz et al. (2025) studied this question.

synapsesocial.com/papers/6a97687351c248f2dd31b9df https://doi.org/10.1111/hdi.13230

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