Why the study?
Does intravenous NaHCO3 improve metabolic parameters and survival in diabetic dogs with phenformin-induced lactic acidosis compared to NaCl or no therapy?
Does intravenous NaHCO3 improve metabolic parameters and survival in diabetic dogs with phenformin-induced lactic acidosis compared to NaCl or no therapy?
In a canine model of lactic acidosis, intravenous NaHCO3 worsened cardiac output and intracellular pH without improving mortality, challenging its rationale as a standard therapy.
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NaHCO3 may worsen hemodynamics and pHi without mortality benefit in this model; leaves open its clinical role pending human data.
Arieff et al. (1982) studied this question.
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