What question did this study set out to answer?

To assess the systemic, metabolic, and hemodynamic consequences of sodium bicarbonate administration in an experimental canine model of hypoxic lactic acidosis.

November 1, 1985AJP Renal Physiology

Metabolic effects of sodium bicarbonate in hypoxic lactic acidosis in dogs

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To assess the systemic, metabolic, and hemodynamic consequences of sodium bicarbonate administration in an experimental canine model of hypoxic lactic acidosis.
Severe hypoxic lactic acidosis was induced in anesthetized dogs via mechanical ventilation with 8% O2 / 92% N2 until arterial PO2 was < 30 mmHg, pH was < 7.20, bicarbonate was < 12 mM, and lactate was > 7 mM.
Following induction, animals were treated for 60 minutes with either intravenous NaHCO3, intravenous NaCl, or no therapy.
Blood pH and bicarbonate declined further over 60 minutes across all three groups without significant divergence between treatments.
Animals treated with NaHCO3 developed significantly higher blood lactate levels than those receiving NaCl or no therapy, driven by a significant increase in gut lactate production.
NaHCO3 therapy uniquely precipitated a reduction in liver and gut blood flow, worsened liver intracellular acidosis through increased tissue lactate and CO2 load, and failed to improve liver lactate extraction.

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Implication

Experimental study finds that sodium bicarbonate elevates blood lactate and reduces splanchnic blood flow in hypoxic dogs, indicating bicarbonate therapy exacerbates hypoxic lactic acidosis.

Cite This Study

Graf et al. (1985) studied this question.

synapsesocial.com/papers/6a978c962855ae6cf374bd13 https://doi.org/10.1152/ajprenal.1985.249.5.f630

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Implication

Experimental study finds that sodium bicarbonate elevates blood lactate and reduces splanchnic blood flow in hypoxic dogs, indicating bicarbonate therapy exacerbates hypoxic lactic acidosis.

Metabolic effects of sodium bicarbonate in hypoxic lactic acidosis in dogs

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Discussion

Implication

Cite This Study

Metabolic effects of sodium bicarbonate in hypoxic lactic acidosis in dogs

Key Points

Discussion

Implication

Cite This Study

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