Population
Chloralose-anesthetized paralyzed artificially ventilated cats with denervated cardiopulmonary, baro-, and…
Comparison
Respiratory acidosis or isocapnic metabolic… vs Control level with normal blood gases
Design
Preclinical
Authors
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Respiratory acidosis may elicit greater SNA increases than metabolic acidosis in animals; leaves open CO2-specific sympathetic mechanisms in human cardiovascular disease.
Systemic CO2 and H+ concentrations represent different stimuli to the sympathetic nervous system, with respiratory acidosis causing a more pronounced increase in sympathetic nerve activity than metabolic acidosis.
Offner et al. (1994) studied this question.
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