Why the study?
Does respiratory acidosis alter the ECG and pressor responses to sympathomimetic agents in dogs?
Population
Dogs (intact and subjected to total cardiac by-pass)
Comparison
Sympathomimetic agents under conditions of… vs Sympathomimetic agents at normal blood pH
Design
Preclinical
Authors
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Warrants caution extrapolating sympathomimetic dosing to acidotic patients; leaves open translation from canine models to human care.
Does respiratory acidosis alter the ECG and pressor responses to sympathomimetic agents in dogs?
Respiratory acidosis diminishes the pressor response and minimizes ECG abnormalities induced by sympathomimetic agents in dogs.
Houle et al. (1957) studied this question.
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