Why the study?
Does respiratory acidosis alter the circulatory effects of epinephrine in anesthetized dogs?
Population
Anesthetized intact dogs after sympathetic and parasympathetic block
Design
Preclinical
Authors
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Respiratory acidosis may blunt epinephrine inotropy in dogs; hypothesis-generating, requires human validation before clinical extrapolation.
Does respiratory acidosis alter the circulatory effects of epinephrine in anesthetized dogs?
Respiratory acidosis blunts the inotropic effect of epinephrine but not its chronotropic or vasopressor effects, and repeated epinephrine infusions lead to differential tachyphylaxis of contractile force.
Bendixen et al. (1963) studied this question.
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